Pituitary-Gonadal Axis Hormone and Semen Analysis in Narcotic Dependency

AUTHORS

Raheleh Assaei 1 , * , Hedayat Nazari 2 , Naser Pajouhi 3 , Saleh Zahedi-Asl 4

AUTHORS INFORMATION

1 Department of Physiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran

2 Department of Psychiatry, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran

3 Department of Physiology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

4 Endocrine Research Center, Shahid Beheshti University, Tehran, Iran

How to Cite: Assaei R, Nazari H, Pajouhi N, Zahedi-Asl S. Pituitary-Gonadal Axis Hormone and Semen Analysis in Narcotic Dependency , Zahedan J Res Med Sci. 2013 ; 15(4):e93008.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (4); e93008
Published Online: November 05, 2012
Article Type: Research Article
Received: November 02, 2011
Accepted: January 12, 2012

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Abstract

Background : Drug abuse is associated with numerous complications including hormonal disorders of hypothalamic-pituitary-gonadal axis and spermatogenic disorders. We have compared the hormone concentration of pituitary-gonadal axis and the semen analysis in opioid-dependent and non-opioid-dependent men.
Materials and Methods : In this case-control study, serum concentration of pituitary- gonadal axis hormones and semen analysis in 48 opioid-dependent men as eligible to participate in the study were compared with those in 12 non-dependent men.
Results : Free testosterone concentration in all test groups was significantly less than that in control group. Furthermore, the concentration of Dihydrotestosterone (DHT) and Dehydroepiandrosterone Sulfate (DHEAS) in all test groups except those addicted to heroin was less than in those in control group. Concentrations of LH, FSH, prolactin, SHBG, progesterone and estradiol, normal and abnormal sperm count in test groups were significantly different from control group. However, in all test groups, sperm motility rate was less than control group. No significant relationship was found between the concentration of sex hormones and the status of sperms motility.
Conclusion : Chronic use of opioids will affect testosterone hormone and sperm, and it will cause hypogonadism and impairment of sperm motility.

Keywords

Addiction Sex Hormones Semen Analysis

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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