Serum Lipid Profile in Psoriatic Patients in Kermanshah: A Survey on Vascular Adhesion Protein-1

AUTHORS

Houshang Nemati 1 , * , Reza Khodarahmi 2 , Masoud Sadeghi 3 , Ameneh Rahmani 3 , Mansour Rezaei 4

AUTHORS INFORMATION

1 Department of Pharmaceutics ,Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

3 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

4 Department of Biostatistics ,Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Nemati H, Khodarahmi R, Sadeghi M, Rahmani A, Rezaei M. Serum Lipid Profile in Psoriatic Patients in Kermanshah: A Survey on Vascular Adhesion Protein-1 , Zahedan J Res Med Sci. 2013 ; 15(2):e93082.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (2); e93082
Published Online: October 28, 2012
Article Type: Research Article
Received: November 19, 2011
Accepted: December 14, 2011

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Abstract

Background : Psoriasis is a chronic inflammatory skin disease characterized by excessive cellular replication. Vascular adhesion protein-1 (VAP-1) is an adhesion molecule with an enzymatic activity that partakes in the migration process of lymphocytes into sites of inflammation. The current study aimed to investigate the plasma lipids and VAP-1 in serum of psoriatic patients in Kermanshah (Iran).
Materials and Methods :  This was a descriptive analytical study carried out on 80 psoriatic patients, and 80 healthy volunteers as control group. Serum lipids (triglyceride (TG), cholesterol (Ch), HDL-cholesterol and LDL-cholesterol) were determined by enzymatic methods. The level of VAP-1 protein was evaluated by ELISA method.
Results : The mean levels of cholesterol, TG, HDL and LDL in patients were 167.7, 123.4, 44.1 and 112.3 mg/dl, respectively. However, these values in control group were 156.7, 113.3, 45.5 and 102.4 mg/dl, respectively. In addition, the mean of VAP-1 protein in psoriatic patients and control group was 289.8 and 192.7 ng/ml, respectively. Cholesterol level and VAP1 protein in psoriatic patients were found to be significantly higher than those of control group.
Conclusion : The current study showed that the levels of cholesterol and VAP-1 in psoriasis patients were significantly higher than control group. This higher level may be account for high prevalence of cardiovascular diseases among these patients and it may be useful to do early screening and treatment of psoriatic patients to prevent the atherosclerosis and its complications.

Keywords

Psoriasis VAP-1 Lipids

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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