Role of Cervical IL-6 and IL-8 Levels in Preterm Labor in Nulliparous Pregnant Women

AUTHORS

Sholeh Shahgheibi 1 , Abdorrahim Afkhamzadeh 2 , Narjes Noori 1 , *

1 Department of Obstetrics and Gynecology, Kurdistan University of Medical Sciences, Kurdistan, Iran

2 Department of Social Medicine, Digestion and Liver Research Center, Kurdistan University of Medical Sciences, Kurdistan, Iran

How to Cite: Shahgheibi S, Afkhamzadeh A, Noori N. Role of Cervical IL-6 and IL-8 Levels in Preterm Labor in Nulliparous Pregnant Women, Zahedan J Res Med Sci. 2013 ; 15(2):e93083.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (2); e93083
Published Online: October 28, 2012
Article Type: Research Article
Received: December 04, 2010
Accepted: April 26, 2012

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Abstract

Background : Premature birth is a cause of prenatal mortality and covers 60-80% of deaths caused by the congenital defects. Despite eye-catching developments in medical sciences, premature birth statistics are still high and impose hefty costs on the society. Laboratory indexes such as IL-6 and IL-8 are used to predict the preterm delivery. In this study, the role of IL-6 and IL-8 of cervix in women with preterm labor and term delivery were compared.
Materials and Methods : This case-control study was performed on 89 patients, 60 patients in control group and 29 patients in the study group, who had symptoms of preterm labor. Endocervical swab samples were collected from all patients in order to study IL-6 and IL-8 levels using ELISA technique. SPSS-15 statistical software was used for the analysis of data. T-test was used to assess different qualitative variables.
Results : 78 patients (87.63%) and 11 patients (12.35%) had term and premature deliveries, respectively. The two groups had not significant difference in terms of weight and size. A significant statistical difference only in cervix IL-8 was observed between the two term and preterm groups after comparison of the mean variables.
Conclusion : Cervico-vaginal level of IL-8 in premature deliveries is higher than term deliveries and it can be used to predict premature delivery.

Keywords

Interleukin-6 Interleukin-8 Preterm labor Nulliparity

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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