Evaluation of Chemoprevention Effect of Systemic Celecoxib on Induction of Tongue Neoplasms in Rat

AUTHORS

Fateme Arbabi-Kalati 1 , * , Mehran Mesgari-Abbasi 2 , Mojgan Nasirinasab 3 , Maryam Sohrabi 4 , Leila Roshangar 5 , Jafar Soleimanirad 5 , Amir A. Khaki 5 , Yousof Doustar 6 , Yousof Javadzade 7

1 Department of Oral Medicine, Genetics of Non Communicable Disease Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran

2 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

3 Dentist, Zahedan University of Medical Sciences, Zahedan, Iran

4 Department of Anatomical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran

5 Department of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

6 Department of Pathology, Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran

7 Department of Pharmacology, Tabriz University of Medical Sciences, Tabriz, Iran

How to Cite: Arbabi-Kalati F , Mesgari-Abbasi M, Nasirinasab M, Sohrabi M, Roshangar L, et al. Evaluation of Chemoprevention Effect of Systemic Celecoxib on Induction of Tongue Neoplasms in Rat, Zahedan J Res Med Sci. 2013 ; 15(1):e93130.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (1); e93130
Published Online: January 17, 2011
Article Type: Research Article
Received: May 05, 2010
Accepted: June 15, 2010

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Abstract

Background : Cyclo-oxygenase-2 (COX-2) specific inhibitors were examined for predication or treatment of different tumors and it is indicated that COX-2 specific inhibitors play an important regulatory role in apoptosis of tumoral tissues. Therefore, the present study was designed in order to examine the preventive effects of a COX-2 specific inhibitor called celecoxib on 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinoma on rat.
Materials and Methods : In this experimental study, 30 Sprague Dawley rats (with the age of 3- 3.5 months) were selected and divided into three groups. In order to induce lingual carcinoma, 4NQO powder was prepared 3 times a week for each cage. In this study, celecoxib power was mixed with a basic food (basal diet) in order to examine the systematic effect. Tongue samples were sent to laboratory for immunohistochemical (IHC) staining and histological examination.
Results : Based on morphological criteria and the ratio of apoptosis to cell proliferation, the prevalence of tongue precancerous lesions was reduced significantly by celecoxib.
Conclusion : Celecoxib systematic has inhibitory effects on the 4-nitroquinoline 1-oxide (4NQO)-induced squamous cell carcinoma of tongue. The effect of celecoxib is probably via suppression of cell proliferation and induction of apoptosis.

Keywords

Chemoprevention Cox2 Inhibitor Oral Cancer

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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