Immunohistochemical Expression of Estrogen and Progesterone Receptors in Epulis Fissuratum

AUTHORS

Maryam Seyedmajidi 1 , * , Shahryar Shafaee 2 , Mohammad Azhdari 3 , soraya khafri 4 , Sepideh Siadati 5 , Mohammad Mehdizadeh 6

AUTHORS INFORMATION

1 Department of Oral & Maxillofacial Pathology, Dental Materials Research Center, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran

2 Department of Pathology, Cellular & Molecular Biology Research Center, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran

3 Dentist, Students' Research Center, Babol University of Medical Sciences, Babol, Iran

4 Department of Biostatistic, Dental Materials Research Center, Babol University of Medical Sciences, Babol, Iran

5 Department of Pathology, Babol University of Medical Sciences, Babol, Iran

6 Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (1); e93135
Published Online: October 15, 2012
Article Type: Research Article
Received: November 03, 2011
Accepted: November 23, 2011

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Abstract

Background : Epulis Fissuratum (Epulis Fissuratum (EF) or Denture Epulis or inflammatory fibrous hyperplasia) is a common hyperplastic tumor-like lesion with reactive nature, related to loose and ill-fitting, full or partial removable dentures and it is more common in women than men. For this reason, hormonal influences may also play role in its creation. The effect of steroid hormones especially sex hormones (Estrogen and progesterone) on oral mucosa is identified in some studies. In the present study, the distribution pattern and presence of estrogen and progesterone receptors in epithelial, stromal, endothelial and inflammatory cells in Epulis Fissuratum was investigated.
Materials and Methods : This cross-sectional study was carried out on 30 samples of paraffin blocks with Epulis Fissuratum diagnosis and 30 samples of normal mucosal tissues as a control group who have had surgery as a margin beside the above lesions and had been obtained from the oral and maxillofacial pathology departement of Babol Dental School since 2003 up to 2010. Intensity of staining and immunoreactivity were evaluated using subjective index and considering the positive control group (breast carcinoma).
Results : Epithelial, stromal, endothelial and inflammatory cells didn’t show reaction with monoclonal antibodies against estrogen and progesterone in none of the samples.
Conclusion : It seems that the hypothesis of the existence of estrogen and progesterone receptors in epulis fissuratum and normal oral mucosa is ruled out. The possibility of direct effect of estrogen and progesterone in occurring of epulis fissuratum is rejected.
 

Keywords

Estrogen Progesterone Receptor Epulis fissuratum

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