The Antimicrobial Activity of Grape Seed Extract against Two Important Oral Pathogens

AUTHORS

Mahkameh Mirkarimi 1 , * , S.Mahmoud Amin-Marashi 2 , Majid Bargrizan 3 , Amir Abtahi 4 , Abbas Ali Imani Fooladi 5

1 Department of Pediatric Dentistry, Children and Adolescent Health Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran

2 Department of Microbiology and Immunology, Babol University of Medical Sciences, Babol, Iran

3 Department of Pediatric Dentistry, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Dentist, Tehran, Iran

5 Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

How to Cite: Mirkarimi M, Amin-Marashi S, Bargrizan M, Abtahi A, Imani Fooladi A A. The Antimicrobial Activity of Grape Seed Extract against Two Important Oral Pathogens, Zahedan J Res Med Sci. 2013 ; 15(1):e93147.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (1); e93147
Published Online: October 14, 2012
Article Type: Research Article
Received: March 05, 2012
Accepted: July 25, 2012

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background : The antimicrobial properties of plant extracts have shown promise for development of new drugs. This study was conducted to measure the antibacterial activity of grape (Vitis vinifera) seed extract against Streptococcus mutans and Aggregatibacter actinomycetemcomitans.
Materials and Methods : In this experimental study the grape seed extract have been prepared with maceration method. The antimicrobial activity of the extract was examined by determining Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) using the macro dilution broth technique.
Results : MIC and MBC for Aggregatibacter actinomycetemcomitans was 3.84 mg/mL and 7.68 mg/mL respectively.There were not any inhibitory effects against Streptococcus mutans.
Conclusion : The Grape seed extract has inhibitory and bactericidal effects against Aggregatibacter actinomycetemcomitans. There were not any bactericidal or bacteriostatic effects against Streptococcus mutans.
 

Keywords

Streptococcus mutans Aggregatibacter actinomycetemcomitans Grape seed extract

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

The full text of this article is available on the PDF file.

References

  • 1.

    The References of this article are available on the PDF file.

  • COMMENTS

    LEAVE A COMMENT HERE: