Association of Calcium-Sensing Receptor (CASR rs 1801725) with Colorectal Cancer

AUTHORS

Akram Safaei 1 , * , Elaham Arbabi-Aval 1 , Maral Arkani 1 , Khatun Karimi 1 , Fatemeh Rostami 1 , Mohsen Vahedi 1 , Fateme Khorshidi 1 , Mitra Iman 1 , S. Reza Mohebi 1 , Mohamad Vafae 2 , S. Reza Fatemi 1 , Mohammad Reza Zali 1

AUTHORS INFORMATION

1 Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Iranian Ostomy Society, Tehran, Iran

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 14 (7); e93315
Published Online: December 25, 2011
Article Type: Research Article
Received: August 20, 2011
Accepted: October 10, 2011

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Abstract

Background: Calcium induces apoptosis in intestinal epithelial cells and subsequently prevents colorectal cancer through ion calcium receptor. Calcium-sensing receptor mutation reduces the expression of this receptor, and subsequently in reduces calcium transportation. Many studies have shown that Calcium-sensing receptor gene polymorphism may increase the risk of colorectal cancer. The purpose of this study is to assess the prevalence of calcium-sensing receptor polymorphisms (rs 1801725) in Iran society and to examine the role of this polymorphism in the increased risk of colorectal cancer (CRC).
Materials and Methods: The research was a case-control study. 105 patients with colorectal cancer and 105 controls were randomly studied using polymerase chain reaction and restriction fragment length polymorphism. χ2 test  and software 16- SPSS were used for statistical analysis.
Results: In patient samples, the frequency of the genotypes TT, GT, GG in gene CASR rs 1801725 was respectively 64.8, 32.4, and 2.9 and the frequency of this polymorphism in control samples was respectively 51.2, 45.7, and 2.9. Frequency of allele G in patient samples was 0/48 and frequency of allele T was 0.25. In addition, Frequency of allele G in control samples was 0.74 and Frequency of allele T was calculated 0.19.
Conclusion: The results show that calcium-sensing receptor variant (1801725 rs) is not associated with increased risk of colorectal cancer.

Keywords

Rs 1801725 Colorectal cancer Polymerase chain reaction Restriction fragment length polymorphism Calcium-sensing receptor

© 2012, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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