Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Effects of Manganese Exposure on Blood Iron Indices in Miners of Iran Manganese Mines Co. (Qom)

Seyyed Mohammad Hossein Razavian 1 , *
Author Information
1 Department of Microbiology, Faculty of Sciences, Qom Branch, Islamic Azad University, Qom, Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: April 2017, 19 (4); e9358
  • Published Online: April 30, 2017
  • Article Type: Research Article
  • Received: November 2, 2016
  • Revised: January 22, 2017
  • Accepted: April 21, 2017
  • DOI: 10.5812/zjrms.9358

To Cite: Razavian S M H. Effects of Manganese Exposure on Blood Iron Indices in Miners of Iran Manganese Mines Co. (Qom), Zahedan J Res Med Sci. 2017 ; 19(4):e9358. doi: 10.5812/zjrms.9358.

Copyright © 2017, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Bahrami A, Jafari A, Asilian H, Taghizadeh M, Arjmand A, Akbari H. Biomarkers of occupational manganese toxicity. Biosci Biotechnol Res Asia. 2015; 12(3): 2147-56[DOI]
  • 2. Jiang Y, Zheng W, Long L, Zhao W, Li X, Mo X, et al. Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: search for biomarkers of manganese exposure. Neurotoxicology. 2007; 28(1): 126-35[DOI][PubMed]
  • 3. Montes S, Riojas-Rodriguez H, Sabido-Pedraza E, Rios C. Biomarkers of manganese exposure in a population living close to a mine and mineral processing plant in Mexico. Environ Res. 2008; 106(1): 89-95[DOI][PubMed]
  • 4. Aschner M, Higdon J. Micronutrient research for optimum health 2010;
  • 5. Nastiti A, Oginawati K, Santoso M. Manganese exposure on welders in small-scale mild steel manual metal arc welding industry. J Appl Sci Environ Sanit. 2010; 5(3)
  • 6. Guilarte TR. Manganese and Parkinson's disease: a critical review and new findings. Cien Saude Colet. 2011; 16(11): 4549-66[DOI][PubMed]
  • 7. Razavian H, Mohammad S, Rabiee M. Evaluation of liver biochemical parameters in manganese miners. Zahedan J Res Med Sci. 2014; 16(6): 64-7
  • 8. Pejovic-Milic A, Chettle DR, McNeill FE. Quantification of manganese in human hand bones: a feasibility study. Phys Med Biol. 2008; 53(15): 4081-92[PubMed]
  • 9. Finley BL, Santamaria AB. Current evidence and research needs regarding the risk of manganese-induced neurological effects in welders. Neurotoxicology. 2005; 26(2): 285-9[DOI][PubMed]
  • 10. Hassanzadeh GT, Moshtaghi AA. Interrelation between manganese and iron metabolism in rat (in vivo studies). 2002; 13(3): 205-12
  • 11. Hassanzadeh Ghasabeh T. Survey correlation iron and manganese in conjuncture to Apo-transferrin. Hamedan Univ Med Sci. 2003; 10(2): 36-41
  • 12. Badiei K, Parchami A. Measurement of manganese concentrations in serum, liver, heart, muscle, spleen and hair in dromedary camels of Yazd province. Pajouhesh and Sazandegi. 2004; 64: 81-4
  • 13. Smith EA, Newland P, Bestwick KG, Ahmed N. Increased whole blood manganese concentrations observed in children with iron deficiency anaemia. J Trace Elem Med Biol. 2013; 27(1): 65-9[DOI]
  • 14. Pesch B, Weiss T, Kendzia B, Henry J, Lehnert M, Lotz A, et al. Levels and predictors of airborne and internal exposure to manganese and iron among welders. J Expo Sci Environ Epidemiol. 2012; 22(3): 291-8[DOI][PubMed]
  • 15. Lander F, Kristiansen J, Lauritsen JM. Manganese exposure in foundry furnacemen and scrap recycling workers. Int Arch Occup Environ Health. 1999; 72(8): 546-50[DOI][PubMed]
  • 16. Lu L, Zhang LL, Li GJ, Guo W, Liang W, Zheng W. Alteration of serum concentrations of manganese, iron, ferritin, and transferrin receptor following exposure to welding fumes among career welders. Neurotoxicology. 2005; 26(2): 257-65[DOI][PubMed]
  • 17. Chua AC, Morgan EH. Effects of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat. Biol Trace Elem Res. 1996; 55(1-2): 39-54[PubMed]
  • 18. Bowler RM, Gocheva V, Harris M, Ngo L, Abdelouahab N, Wilkinson J, et al. Prospective study on neurotoxic effects in manganese-exposed bridge construction welders. Neurotoxicology. 2011; 32(5): 596-605[DOI][PubMed]
  • 19. Logroscino G, Marder K, Graziano J, Freyer G, Slavkovich V, LoIacono N, et al. Altered systemic iron metabolism in Parkinson's disease. Neurology. 1997; 49(3): 714-7[PubMed]
  • 20. Zheng W, Zhao Q, Slavkovich V, Aschner M, Graziano JH. Alteration of iron homeostasis following chronic exposure to manganese in rats. Brain Res. 1999; 833(1): 125-32[PubMed]
  • 21. Finley JW. Manganese absorption and retention by young women is associated with serum ferritin concentration. Am J Clin Nutr. 1999; 70(1): 37-43[PubMed]
  • 22. Klausner RD, Rouault TA, Harford JB. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell. 1993; 72(1): 19-28[DOI][PubMed]
  • 23. Aschner M, Vrana KE, Zheng W. Manganese uptake and distribution in the central nervous system (CNS). Neurotoxicology. 1999; 20(2-3): 173-80[PubMed]
  • 24. Iron metabolism: Physiology and pathophysiology. J Trace Elem Exp Med. 2000; 13(1): 73-83[DOI]
  • 25. Hassani H, Golbabaei F, Ghahri A, Hosseini M, Shirkhanloo H, Dinari B, et al. Occupational exposure to manganese-containing welding fumes and pulmonary function indices among natural gas transmission pipeline welders. J Occup Health. 2012; 54(4): 316-22[PubMed]
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