The effects of cellular phone waves on the frequency micronucleus in newborn and adult Balb/C mouse

AUTHORS

Javad Baharara 1 , * , Farhang Hadad 2 , Mohammad A. Shariatzade 3 , Maryam Amirahmadi 4

AUTHORS INFORMATION

1 Associate Professor of Animal Developmental Biology, School of Basic Sciences, Islamic Azad University Mashhad Branch, Mashhad, Iran.

2 Assistant Professor of Cell Genetics, School of Basic Sciences, Ferdowsi University, Mashhad, Iran.

3 Professor of Histology& Embryology, School of Basic Sciences, Arak University, Arak, Iran.

4 MSc of Cell& Developmental Biology, School of Basic Sciences, Islamic Azad University, Mashhad Branch, Mashhad Iran

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 13 (4); e93932
Published Online: May 27, 2011
Article Type: Research Article
Received: September 13, 2010
Accepted: September 14, 2010

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Abstract

Background: In recent years, the widespread use of microwave producing instruments specially cell phones result in growing concern regarding the possible effects associated with these waves on human health especially pregnant woman and neonates. In present study, we investigated the genotoxic effects of cell phone radiation on the mice (Balb/C) and their offspring.

Materials and Method: In this experimental research, pregnant mice were irradiated with cell phone for 4 days of gestational age (days 14th-18th, 6h per day, from 9am until 3pm) and after litter, 2nd-day offspring studied for morphology, weight and CR length. By following, for assessment of possible genetic damages in erythrocytes after bleeding from heart, smears of spleen tissue prepeard for histological studies. Mice peripheral blood and bone marrow smears prepared and stained with May-Granowald and Gimsa.

Results: The finding in experimental group indicated that cell phone radiation decreased offsprings’ weight and CR length (p<0.001). Megakaryocytes in marrow (p=0.02) and red blood cells in spleen (p=0.03) were increased but were not shown any changes in lymphocytes (p>0.05). An increase in micronucleus frequency in peripheral blood erythrocytes were seen in experimental newborn (p=0.006) and adult mice (p<0.001) but we did not found any change in the frequency of micronuclei in adult mice bone marrow polychromatic erythrocytes (p>0.05).

Conclusion: Above findings indicated that cell phone radiation (940 MHZ) are able to increase the frequency of micronucleus in peripheral blood erythrocytes of adult mice and their of fsprings and induce a genotoxic response.

Keywords

Cell phone micronucleus bone marrow blood Balb/C

© 2011, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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