Relationship between loss of exercise consequences and risk of cardiovascular diseases after detraining


Mehdi Mogharnasi 1 , * , Mahtab Nasseh 2


1 Assistant Professor of Sport Physiology, University of Sistan and Balouchestan, Zahedan, Iran.

2 MSc Student of Physical Education, University of Sistan and Balouchestan, Zahedan, Iran.


Zahedan Journal of Research in Medical Sciences: 13 (2); e94061
Published Online: January 05, 2011
Article Type: Research Article
Received: March 17, 2010
Accepted: July 28, 2010




Background: The studies show that regular exercise may play an important role in improvement the cardiovascular status and with detraining period people will loose its useful outcome. The aim of this study was to assess the effect of short detraining period on cardiovascular biomarkers in Wistar rats.
Materials and Method: Forty-two male rats were divided randomly in two groups: experimental group (n=24) and control group (n=18). The training program was done 3 times per week, for 8 weeks. Then six rats experienced detraining. The blood samples were collected after 14 fasting hours in different stages and with the same conditions. The quantity of sICAM-1 was measured, using the commercial R&D Elisa kit. The quantity of total cholesterol (TC), triglyceride (TG), HDL & LDL in plasma was measured by using Pars-Azmoon kits. Data were analyzed by Kolmogrov-Smirnov, repeated measures of ANOVA, LSD and t-test. The amount of errors were computed in the level of p<0.05.
Results: Thirty-six sessions of aerobic training made significant changes in variables and after 4 weeks of detraining the amount of measured variables were changed in to the insignificant baseline level. There were significant changes when detraining group compared with training group at the end of study [sICAM-1 (p=0.006), TC (p=0.004), TG (p=0.005) & LDL-C (p=0.037), HDL-C (p=0.037)].
Conclusion: The results showed, detraining casuses the increase of dangerous factors and body faces the risk of cardiovascular diseases and atherosclerosis.


Aerobic exercise detraining cardiovascular biomarkers atherosclerosis

© 2011, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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