The effect of melatonin and luzindole on spatial learning and memory in rats treated with darkness

AUTHORS

Mahmoud Salami 1 , Gholamali Hamidi 2 , S. Alireza Talaei-Zavareh 3 , *

AUTHORS INFORMATION

1 Associate Professor of Physiology, Physiology Research Center, Kashan University of Medical Sciences and Health Services, Kashan, Iran.

2 Asisstant Professor of Physiology, Physiology Research Center, Kashan University of Medical Sciences and Health Services, Kashan, Iran.

3 Instructor of Physiology, Physiology Research Center, Kashan University of Medical Sciences and Health Services, Kashan, Iran.

How to Cite: Salami M, Hamidi G, Talaei-Zavareh S A. The effect of melatonin and luzindole on spatial learning and memory in rats treated with darkness, Zahedan J Res Med Sci. 2011 ; 13(1):e94080.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 13 (1); e94080
Published Online: October 05, 2010
Article Type: Research Article
Received: May 05, 2010
Accepted: June 15, 2010

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Abstract

Background : During critical periods of growth, evolution dependent of sensory experience has a deep effect on the formation and proper function of mammal’s CNS. The aim of this study is to assess the interaction of melatonin and its antagonist, luzindole on rat’s spatial learning and memory processes treated in darkness using the Morris Water Maze (MWM).

  Materials and Method : This experimental study was carried out on 60 Wistar male rats of 45 days which randomly distributed in two groups. Animals of the control group experienced 12 hour-periods of darkness & light and the test group developed in complete darkness. Each group has 3 subgroups: Control, receiving Melatonin and receiving Luzindole (n=10 for each). Using MWM, the learning process and memory consolidation of animals were evaluated for 5 nights and 4 times each night.

  Results: The results of this study showed that the learning stage in animals deprived of light phase needed more time to find the platform than the control group (p=0.011). Also, melatonin can increase this time in the control rats (p=0.012). Darkness treatment and melatonin were not effective on memory consolidation of these animals. Luzindole in control rats needed less time spending in the target quadrant (p=0.009).

  Conclusion : Darkness treatment causes impairment in spatial learning process in rats and melatonin will make it difficult spatial learning in control animals. None of the above two interventions are effective on the process of memory consolidation.

Keywords

Darkness photic stimulation maze learning melatonin luzindole rat

© 2011, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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