Broad spectrum antibacterial activity of peracetic acid (Percidin)

AUTHORS

Abdolvahab Moradi 1 , * , Mehdi Shahmoradi 2 , Ezzatollah Ghaemi 1 , Alijan Tabaraii 3 , Maryam Sadegh-Sheshpoli 4 , Masoud Bazori 4 , Hadi Koohsari 5

AUTHORS INFORMATION

1 Associate Prof, Dept of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences and Health Services, Gorgan, Iran

2 MD, Behban Chemi Co, Gorgan, Iran

3 Assistant Prof, Dept of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences and Health Services, Gorgan, Iran

4 BSc of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences and Health Services, Gorgan, Iran

5 Instructor, Dept of Microbiology, Islamic Azad University, Azad-Shahr branch

How to Cite: Moradi A, Shahmoradi M, Ghaemi E, Tabaraii A, Sadegh-Sheshpoli M, et al. Broad spectrum antibacterial activity of peracetic acid (Percidin), Zahedan J Res Med Sci. 2009 ; 11(1):e94443.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 11 (1); e94443
Published Online: February 20, 2009
Article Type: Research Article
Received: November 16, 2008
Accepted: January 26, 2009

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Peracetic acid (Percidin) is a chemical compound that shows antimicrobial activity due to its high oxidizing potential. This study was designed to evaluate the efficiency of antibacterial activity of Percidin and its spectrum by disc diffusion and microdilution methods.

Materials and Methods: Standard strains and isolated bacteria from clinical specimens in the north of Iran were used in this work. Different dilutions of percidine and discs were prepared. Disc diffusion test was done and inhibition zone was measured. Finally, MIC and MBC was determined by microdilution methods.

Results: Our results demonstrated highest susceptibility of Staphylococcus aureus strains that were sensitive and resistant to methiciline. Lower level of susceptibility to percidin was seen for Bacillus licheniformis. Inhibition zone for gram negative bacteria was between 34 and 45 mm. Almost both MIC and MBC for gram positive bacteria was 2µg/ml and maximum amount obtained in Mycobacterium smegmatis and Entrococcus fecalis with 4µg/ml and 8µg/ml simultaneously. The MIC was 4µg/ml in gram negative bacteria.

Conclusion: The analysis of percidin antibacterial activity against different types of bacteria shows its wide antibacterial spectrum that covers gram-positive and gram-negative bacteria including standard and clinical isolated strains. The coincidence of most of the MIC and the MBC indicates the bactericidal activity for Percidin. In brief, this work describes a broad-spectrum antibacterial activity of Percidin and suggests use of this compound as a strong disinfectant in hospitals and elimination of bacteria from medical equipments.

Keywords

Percidin Peracetic acid Gram positive bacteria Gram negative bacteria MIC MBC

© 2009, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

The full text of this article is available on the PDF file.

 

References

  • 1. The References of this article are available on the PDF file.
  • COMMENTS

    LEAVE A COMMENT HERE: