Changes in Pre-Inflammatory Cytokines and Markers of Vascular Inflammation after Regular Endurance Training


Mehdi Mogharnasi 1 , * , Abbas Gaeini 2 , Dariush Sheikholeslami vatani 3


1 Dept of Physical Education and Sport Sciences, University of Sistan and Baluchestan, Zahedan, Iran.

2 Dept of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

3 Dept of Physical Education and Sport Sciences, University of Kurdistan, Sanandaj, Iran


Zahedan Journal of Research in Medical Sciences: 10 (2); e94534
Published Online: May 13, 2008
Article Type: Research Article
Received: February 03, 2008
Accepted: April 07, 2008




Background: Growing evidence indicates that pre-inflammatory cytokines and cellular adhesion
molecules that increase vascular endothelial activity are more sensitive in anticipating
cardiovascular diseases. These novel inflammatory markers may play an important role in
pathogenesis of atherosclerosis. The purpose of this study was to determine the changes in preinflammatory
cytokines and markers of vascular inflammation after regular endurance training in
Wistar rats.
Materials and Methods: In this experimental study, 24 male rats (3 months old) were kept in a
controlled condition and were divided into two different control (n=12, weight=211±3gr) and
experimental (n=12, weight=208±7gr) groups. The training program was performed 3 times a
week for 12 weeks under certain duration and speed. The blood sampling was performed after 14
fasting hours in different stages and with the same conditions. Elisa trade kits were used to measure
sICAM-1, TNF-a, and IL-1β. Resulting data were analyzed by dependent and independent t-tests
Results: A significant increase was observed in IL-1β (p=0.045), TNF-a (p=0.047), and sICAM-
1(p=0.028) levels in control group, while a significant decrease in IL-1β (p=0.002), TNF-a
(p=0.016), and sICAM-1 levels was shown in experimental group (p=0.000). Also, a significant
difference was observed in comparison between control and experimental groups about IL-1β
(p=0.039), TNF-a (p=0.028), and sICAM-1 (p=0.000).
Conclusion: The results of this study showed that regular endurance training (Vo2max 55-85%)
reduces the amounts of inflammatory markers of cardiovascular diseases including sICAM-1, TNFa,
and IL-1β. This training method can play an efficient role in declining the risk of atherosclerosis
by lowering markers of vascular inflammation.


IL-1β TNF-α sICAM-1 Endurance training Inflammatory Atherosclerosis.

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