Histopathological Effects of Soldering Fumes on Respiratory Tract Epithelium in Rat

AUTHORS

Mohammad reza Arab 1 , * , Ramazan Mirzaei 2 , Mehrbod Karimi 3 , AbbasAli Moin 1 , Rezvaneh Mashhadi 4

AUTHORS INFORMATION

1 Dept of Anatomy, Faculty of Medicine, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

2 Dept of Proportional Health, Faculty of Medicine, Zahedan University of Medical Sciences and Health Services Zahedan, Iran.

3 Dept of Pathology, Faculty of Medicine, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

4 Faculty of Medicine, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

How to Cite: Arab M R, Mirzaei R, Karimi M, Moin A, Mashhadi R. Histopathological Effects of Soldering Fumes on Respiratory Tract Epithelium in Rat , Zahedan J Res Med Sci. 2008 ; 10(2):e94536.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 10 (2); e94536
Published Online: June 14, 2008
Article Type: Research Article
Received: December 31, 2007
Accepted: May 26, 2008

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Abstract

Background: Fumes generating during soldering process are a group of metal vapors and gases
such as tin, lead and formaldehyde which are one of the main reasons for lung diseases in solders.
Respiratory epithelium in trachea is the first biological barrier which responds to these fumes. The
aim of this study was to identify the quantitative effects of these fumes in respiratory epithelium of
rats.
Materials and Methods: A total number of 48 adult male Sprague Dawley rats were randomly
divided into experimental (n=30) and control (n=18) groups. Each group was subdivided into 2, 4
and 6-week subgroups based on the time of tissue sampling. After adaptation to standard situation
in animal house, rats in experimental group were exposed to soldering fumes for 1 hour in exposure
chamber (0.83m3). Air sampling from the exposure chamber was done daily with two different
methods. According to the schedule, tissue specimens were taken from trachea in deep anesthesia.
After processing, all samples were sectioned and stained and the thickness of the respiratory
epithelium of trachea was measured under light microscopy.
Results: There was a significant difference between all of control and experimental subgroups
(p<0.000). There was also a significant difference between experimental groups of 6-week
subgroup with 2-week subgroup (p<0.001). The amount of the formaldehyde, tin (Sn) and lead (Pb)
in gas exposure chamber was 0.193 mg/m3, 0.35 mg/m3 and 3 mg/m3 respectively.
Conclusion: It seems that the respiratory epithelium of the trachea responds to the soldering
fumes and the changes in epithelial thickness are time dependent.

Keywords

Soldering fumes respiratory epithelium trachea formaldehyde

© 2008, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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