Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Genetic Overlap Between Affective Disorders: An Association Analysis of M18 and M23 SNPs of DAOA/G72 Gene With Schizophrenia and Bipolar Disorder

Leila Ahmadi 1 , Seyyed Reza Kazeminezhad 1 , * , Niloufar Khajehdin 2 , Mehdi Pourmehdi-Boroujeni 3 and Parisima Behbahani 1
Authors Information
1 Department of Genetics, Faculty of Sciences, Shahid Chamran University, Ahvaz, IR Iran
2 Department of Psychiatry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: May 28, 2015, 17 (5)
  • Published Online: May 31, 2015
  • Article Type: Research Article
  • Received: January 16, 2014
  • Accepted: March 12, 2014
  • DOI: 10.17795/zjrms957

To Cite: Ahmadi L, Kazeminezhad S R, Khajehdin N, Pourmehdi-Boroujeni M, Behbahani P. Genetic Overlap Between Affective Disorders: An Association Analysis of M18 and M23 SNPs of DAOA/G72 Gene With Schizophrenia and Bipolar Disorder, Zahedan J Res Med Sci. 2015 ; 17(5):-. doi: 10.17795/zjrms957.

Copyright © 2015, Zahedan University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. Neurobiology of schizophrenia. Neuron. 2006; 52(1): 139-53[DOI][PubMed]
  • 2. Jansen A, Krach S, Krug A, Markov V, Thimm M, Paulus FM, et al. The effect of G72 genotype on neural correlates of memory encoding and retrieval. Neuroimage. 2010; 53(3): 1001-6[DOI][PubMed]
  • 3. Cherlyn SY, Woon PS, Liu JJ, Ong WY, Tsai GC, Sim K. Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: a decade of advance. Neurosci Biobehav Rev. 2010; 34(6): 958-77[DOI][PubMed]
  • 4. Green MF. Stimulating the development of drug treatments to improve cognition in schizophrenia. Annu Rev Clin Psychol. 2007; 3: 159-80[DOI][PubMed]
  • 5. Owen MJ, Craddock N, O'Donovan MC. Schizophrenia: genes at last? Trends Genet. 2005; 21(9): 518-25[DOI][PubMed]
  • 6. Angst J, Marneros A. Bipolarity from ancient to modern times: conception, birth and rebirth. J Affect Disord. 2001; 67(1-3): 3-19[PubMed]
  • 7. Ginsburg GS, Willard HF. Genomic and Personalized Medicine: V1-2. 2012;
  • 8. Craddock N, Forty L. Genetics of affective (mood) disorders. Eur J Hum Genet. 2006; 14(6): 660-8[DOI][PubMed]
  • 9. Austin J. Schizophrenia: an update and review. J Genet Couns. 2005; 14(5): 329-40[DOI][PubMed]
  • 10. Van Den Bogaert A, Del-Favero J, Van Broeckhoven C. Major affective disorders and schizophrenia: a common molecular signature? Hum Mutat. 2006; 27(9): 833-53[DOI][PubMed]
  • 11. Schiffer HH. Glutamate receptor genes: susceptibility factors in schizophrenia and depressive disorders? Mol Neurobiol. 2002; 25(2): 191-212[DOI][PubMed]
  • 12. Squires RF, Saederup E. A review of evidence for GABergic predominance/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: more support for a continuum hypothesis of "functional" psychosis. Neurochem Res. 1991; 16(10): 1099-111[PubMed]
  • 13. Goff DC, Coyle JT. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry. 2001; 158(9): 1367-77[PubMed]
  • 14. Danbolt NC. Glutamate uptake. Prog Neurobiol. 2001; 65(1): 1-105[PubMed]
  • 15. Meador-Woodruff JH, Healy DJ. Glutamate receptor expression in schizophrenic brain. Brain Res Brain Res Rev. 2000; 31(2-3): 288-94[PubMed]
  • 16. Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 1991; 148(10): 1301-8[PubMed]
  • 17. Lahti AC, Koffel B, LaPorte D, Tamminga CA. Subanesthetic doses of ketamine stimulate psychosis in schizophrenia. Neuropsychopharmacology. 1995; 13(1): 9-19[DOI][PubMed]
  • 18. Detera-Wadleigh S, McMahon F. G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis. Biol Psyc J. 2006; 60(2): 106-14[DOI]
  • 19. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, et al. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A. 2002; 99(21): 13675-80[DOI][PubMed]
  • 20. Hall J, Whalley HC, Moorhead TW, Baig BJ, McIntosh AM, Job DE, et al. Genetic variation in the DAOA (G72) gene modulates hippocampal function in subjects at high risk of schizophrenia. Biol Psychiatry. 2008; 64(5): 428-33[DOI][PubMed]
  • 21. Owen MJ, Williams NM, O'Donovan MC. The molecular genetics of schizophrenia: new findings promise new insights. Mol Psychiatry. 2004; 9(1): 14-27[DOI][PubMed]
  • 22. Lobo A, Perez-Echeverria MJ, Artal J. Validity of the scaled version of the General Health Questionnaire (GHQ-28) in a Spanish population. Psychol Med. 1986; 16(1): 135-40[PubMed]
  • 23. Shi J, Badner JA, Gershon ES, Liu C. Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis. Schizophr Res. 2008; 98(1-3): 89-97[DOI][PubMed]
  • 24. Bass NJ, Datta SR, McQuillin A, Puri V, Choudhury K, Thirumalai S, et al. Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia. Behav Brain Funct. 2009; 5: 28[DOI][PubMed]
  • 25. Mohamad Shariati SA, Behmanesh M, Galehdari H. A study of the association between SNP8NRG241930 in the 5' end of neuroglin 1 gene with schizophrenia in a group of iranian patients. Cell J. 2011; 13(2): 91-6[PubMed]
  • 26. Alizadeh F, Tabatabaiefar M, Ghadiri M, Yekaninejad M, Jalilian N, Noori-Daloii M. Association of P1635 and P1655 polymorphisms in dysbindin (DTNBP1) gene with schizophrenia. Acta Neuropsychiatrica. 2012; 24(3): 155-9[DOI]
  • 27. Galehdari H, Pooryasin A, Foroughmand A, Daneshmand S, Saadat M. Association between the G1001C polymorphism in the GRIN1 gene promoter and schizophrenia in the Iranian population. J Mol Neurosci. 2009; 38(2): 178-81[DOI][PubMed]
  • 28. Galehdari H, Ajam T, Pooryasin A. Combined effect of polymorphic sites in the DTNBP1 and GRIN1 genes on schizophrenia. Iran Islamic Med Rep J. 2010; 24(1): 5-10
  • 29. Soronen P, Silander K, Antila M, Palo OM, Tuulio-Henriksson A, Kieseppa T, et al. Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample. Biol Psychiatry. 2008; 64(5): 438-42[DOI][PubMed]
  • 30. Cardno AG, Rijsdijk FV, Sham PC, Murray RM, McGuffin P. A twin study of genetic relationships between psychotic symptoms. Am J Psychiatry. 2002; 159(4): 539-45[PubMed]
  • 31. Craddock N, O'Donovan MC, Owen MJ. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J Med Genet. 2005; 42(3): 193-204[DOI][PubMed]
  • 32. Berrettini W. Evidence for shared susceptibility in bipolar disorder and schizophrenia. Am J Med Genet C Semin Med Genet. 2003; 123C(1): 59-64[DOI][PubMed]
  • 33. Badner JA, Gershon ES. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry. 2002; 7(4): 405-11[DOI][PubMed]
  • 34. Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, et al. Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet. 2003; 72(5): 1131-40[DOI][PubMed]
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