Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

A Patient With Coinheritance of Alpha-Globin Gene Triplication and IVSI-5 Mutation of Beta-Globin Gene

Majid Naderi 1 , * , Ibrahim Miri-Moghaddam 1 , Akbar Dorgalaleh 2 , Shaban Alizadeh 2 , Shadi Tabibian 2 and Masoud Pishjoo 3
Authors Information
1 Genetic Researcher Center in Non Communicable Disease, Zahedan University of Medical Sciences, Zahedan, IR Iran
2 Department of Hematology, Allied Medical School, Tehran University of Medical Sciences, Tehran, IR Iran
3 Medical Student Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: May 28, 2015, 17 (5)
  • Published Online: May 31, 2015
  • Article Type: Case Report
  • Received: April 11, 2014
  • Accepted: June 24, 2014
  • DOI: 10.17795/zjrms975

To Cite: Naderi M, Miri-Moghaddam I, Dorgalaleh A, Alizadeh S, Tabibian S, et al. A Patient With Coinheritance of Alpha-Globin Gene Triplication and IVSI-5 Mutation of Beta-Globin Gene, Zahedan J Res Med Sci. 2015 ; 17(5):-. doi: 10.17795/zjrms975.

Abstract
Copyright © 2015, Zahedan University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
Footnotes
References
  • 1. Moosavi SF, Amirian A, Zarbakhsh B, Kordafshari A, Mirzahoseini H, Zeinali S, et al. The carrier frequency of alpha-globin gene triplication in an Iranian population with normal or borderline hematological parameters. Hemoglobin. 2011; 35(4): 323-30[DOI][PubMed]
  • 2. Fallah MS, Zadeh-Vakili A, Aleyasin SA, Mahdian R, Karimipour M, Raeisi M, et al. Molecular characterization of thalassemia intermedia, due to co-inheritance of homozygous alpha triplication and IVSI-5 beta-thalassemia. Blood Cells Mol Dis. 2009; 43(2): 158-60[DOI][PubMed]
  • 3. Bragos IM, Noguera NI, Raviola MP, Milani AC. Triplication (/alphaalphaalpha anti3.7) or deletion (-alpha3.7/) association in Argentinian beta-thalassemic carriers. Ann Hematol. 2003; 82(11): 696-8[DOI][PubMed]
  • 4. Galanello R, Ruggeri R, Paglietti E, Addis M, Melis MA, Cao A. A family with segregating triplicated alpha globin loci and beta thalassemia. Blood. 1983; 62(5): 1035-40[PubMed]
  • 5. Traeger-Synodinos J, Kanavakis E, Vrettou C, Maragoudaki E, Michael T, Metaxotou-Mavromati A, et al. The triplicated alpha-globin gene locus in beta-thalassaemia heterozygotes: clinical, haematological, biosynthetic and molecular studies. Br J Haematol. 1996; 95(3): 467-71[PubMed]
  • 6. Kimura EM, Grignoli CR, Pinheiro VR, Costa FF, Sonati MF. Thalassemia intermedia as a result of heterozygosis for beta 0 -thalassemia and alpha alpha alpha anti-3,7 genotype in a Brazilian patient. Braz J Med Biol Res. 2003; 36(6): 699-701[PubMed]
  • 7. Constanco MC, Rocha P, Bento C, Silva HM. [Heterozygous beta thalassemia with triplication of the alpha globin gene]. Portuguese. Acta Med Port. 2011; 24(4): 633-6[PubMed]
  • 8. Camaschella C, Kattamis AC, Petroni D, Roetto A, Sivera P, Sbaiz L, et al. Different hematological phenotypes caused by the interaction of triplicated alpha-globin genes and heterozygous beta-thalassemia. Am J Hematol. 1997; 55(2): 83-8[PubMed]
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