Zahedan Journal of Research in Medical Sciences

Research Article

1/11/2015

Studying the Proteomic Pattern of Cancerous Tissue in Patients With Breast Cancer and Its' Comparing With Healthy Breast

Firooz Behboodi, Mostafa Rezaei Tavirani, Shahrokh Yousefzadeh, Haniyeh Bashizadeh-Fakhar, Behrang Ashoorizadeh, Roya Faraji, Ehsan Kazem-Nejad, Hakimeh Zali

Patients and Methods: In this experimental study, 10 patients with proved breast cancer and 10 patients with healthy breast, healthy and cancerous tissue samples were obtained to perform proteomics. All tissue proteins were purified using standard separation methods and proteins were separated using two-dimensional electrophoresis. Healthy and tumorous tissue proteomes were compared and the extent of protein expression was analyzed.

Research Article

1/11/2015

Effects of Ginger and Elaeagnus angustifolia Extracts in Symptomatic Knee Osteoarthritis

Khadijeh Rabiei, Asieh Ghobadifar, Mohammad Ali Ebrahimzadeh, Majid Saeedi, Maryam Mobini

Patients and Methods: This randomized double-blind clinical trial study carried out on 80 outpatients with knee OA. The patients were randomized to take 200 mg extract of E. angustifolia and ginger or placebo. Knee radiography, serum biochemistry and blood pressure were recorded at baseline and the patients were evaluated for pain intensity, patient and physician global assessment of efficacy, and analgesic use in the past week. The statistical analysis was done using χ² and t-test for comparing the mean values of patients at baseline and after intervention.

Results: Sixty-one patients completed the study. Of all 97.5% of patients were females and the mean of BMI was 30 ± 4.5 kg/m². An entry 53 (66.2%) of patients were receiving analgesics. Eight weeks after the intervention, the patients in drug group had more improvement in pain intensity according to visual analogue scale (VAS) (P = 0.02) and the physician evaluation according to a 4-scale scoring system (P = 0.03), but the analgesic consumption for pain control was not different. Serum biochemistry and ESR did not change after the intervention.

Case Report

1/11/2015

Cerebral Echinococcosis

Reza Ahadi, Ayoob Rostamzadeh, Farhad Naleini, Daryoush Fatehi

Echinococcus granulosus can produce hydatid cysts (HCs) commonly in liver and lung. Central nervous system HCs are rare and comprise 2 - 3%. We found a 25-year-old woman with a medium cerebral HC. She had a rare manifestation, sudden onset of seizure with no other clinical findings 2 hours before admission. Brain CT-scan showed a medium round hypodense lesion at left hemisphere. She had several cystic lesions in right lobe of liver. The cyst was successfully removed without rupture. Although brain HCs is seen mostly in boys, it should be considered in endemic regions, even in young patients with sudden seizure.

Letter

1/11/2015

Measles Elimination Program in Southern Khorasan-e-Razavi From 2001 to 2011

Hamed Ramezani-Awal-Riabi, Alireza Atarodi

Research Article

1/11/2015

Comparison of Executive Function in Obsessive Compulsive Disorder Patients With Good Insight, Poor Insight and Healthy People

Mostafa Toobaei, Mohamad Reza Shairi, Giti Shams, Gholamhosein Ghaedi

Patients and Methods: In this casual comparative study, 22 OCD patients with high insight level, 5 OCD patients with poor insight level (based on YBOCS’ 11th item score) and 23 normal subjects were selected using convenience sampling technique. The subjects were evaluated using two groups of clinical and neuropsychiatric instruments. The clinical instruments included Y-BOCS, BDI-II and GHQ-12. The executive functions were assessed using the Tower of London test, the Stroop and the Wisconsin Card Sorting tests.

Research Article

1/11/2015

Effects of Continuous vs. Intermittent Method of Entonox on Labor Progress

Jila Agah, Roya Baghany, Seyed Hossein Safiabadi-Tali, Yaser Tabarraie

Patients and Methods: This randomized clinical trial was performed in Mobini Hospital, Sabzevar, Iran. One hundred admitted women for vaginal delivery were included in this study. Fitted patients were randomly divided into equal groups. Fifty parturients used it intermittently and 50 persons used it continuously. Then labor progression, maternal and fetal conditions and satisfaction were registered and compared in two groups. Statistical analyses were performed by SPSS-17 software, t-test and χ² test.

Research Article

1/11/2015

Prevalence of Cytomegalovirus Infection in Patients With Ulcerative Colitis by Using PCR Technique

Sahar Mehrabani-Khasraghi, Mitra Ameli, Farzad Khalily, Masood Ghane

Research Article

1/11/2015

Effect of Pentoxifylline on Recurrence in Patients With Multiple Sclerosis: A Non-Randomized Double-Blinded Placebo Controlled Clinical Trial

Akbar Hamzei Moghaddam, Rostam Seiffaddini, Asma Najafzadeh, Hossien Ali Ghaffaripour, Peyman Arasteh, Zeinab Movahhedi, Narges Khanjani

Patients and Methods: In our double-blinded clinical trial study, 44 newly diagnosed relapsing-remitting MS patients were studied for 12 months. They were divided into 2 groups: in group 1, 22 patients received interferon and oral pentoxifylline (800 mg daily for 2 months) and in group 2 (control group), 22 patients received interferon with a placebo. The monthly attack rates and the clinical condition of the patients, using the expanded disability status scale (EDSS), were measured in 3 different times along the study (beginning of the treatment, 6 months after and at the end of the treatment). Analysis of the data was done using t-test and the nonparametric Mann-Whitney U test.

Research Article

1/11/2015

Levels of Zinc, Copper, Magnesium Elements, and Vitamin B12, in Sera of Schoolchildren With Giardiasis and Entrobiosis in Kashan, Iran

Mohsen Arbabi, Nader Esmaili, Karim Parastouei, Hossein Hooshyar, Sima Rasti

Patients and Methods: This case-control study was carried out among 359 children from aged 6 - 12 years old at 8 suburban public schools. Three stool examinations were done using standard techniques for identification parasitic infection. Fifty E. vermicularis and 37 G. lamblia infected individuals were enrolled as study groups. Serum levels of copper, zinc, magnesium were assessed by autoanalyzer and vitamin B12 levels were measured using gamma counter. ANOVA and paired t-test analyses were used to determine the association between infections and trace elements changes.

Results: The prevalence of G. intestinalis and E. vermicularis infections were 10.3% and 13.9%, respectively. The serum zinc, copper and magnesium levels showed a significant decrease in individuals infected with G. intestinalis and E. vermicularis (P < 0.05). Mean values of Giardia positive and negative groups for copper 143.65 ± 16.51 and 176.26 ± 17.6 μg/dL, zinc 62.26 ± 16.06 and 80.66 ± 23.58 μg/dL, and magnesium 1.82 ± 0.23 and 2.01 ± 0.16 mg/dL, respectively. Mean values of Enterobius positive and negative groups for copper 145.55 ± 26.84 and 176.26 ± 17.6 μg/dL, zinc 72.7 ± 17.92 and 80.66 ± 23.58 μg/dL and magnesium 1.93 ± 0.11 and 2.01 ± 0.16 mg/dL, respectively.

Zahedan Journal of Research in Medical Sciences: Nov 2015, 17 (11), 9 articles.