Comparative Study of Sedative and Anxiolytic Effects of Herbal Extracts of Hypericum perforatum with Nardostachys jatamansi in Rats


Ali Rezaei 1 , * , Mehrdad Pashazadeh 2 , Mahdi Pashazadeh 3 , Sajad Moghadam 4

1 Department of Clinical Sciences, Tabr iz Branch, Islamic Azad University, Tabriz, Iran

2 Ahar, Andorra

3 General Physician , Tabri z Branch, Islamic Azad University, Tabriz, Andorra

4 Student of Biology , Ahar Branch , Islamic A zad University, Ahar, Iran

How to Cite: Rezaei A , Pashazadeh M, Pashazadeh M, Moghadam S. Comparative Study of Sedative and Anxiolytic Effects of Herbal Extracts of Hypericum perforatum with Nardostachys jatamansi in Rats, Zahedan J Res Med Sci. 2014 ; 16(3):40-43.


Zahedan Journal of Research in Medical Sciences: 16 (3); 40-43
Published Online: April 28, 2013
Article Type: Research Article
Received: September 02, 2012
Accepted: November 22, 2012




Background: Nardostachys and hypericum due to the effects of sedation, anticonvulsant, analgesic and anti-depressants has especial place in traditional medicine. Principal component and the alkaloid extract of valerian and isovalerate, valeric acid and the extract of hypericum is hypersin and hyperforin.

Materials and Methods: We conducted this study, valerian rhizome by chloroform: methanol (70:30) was extracted in order to obtain total extract produced the N-hexane and studied chemically have been took by Gc-Ms. Hydro-alcoholic extract of aerial valerian tea was prepared for study. In order to study the comparative effects of soothing extracts of valerian and hypericum in different groups of female rat extract of valerian with doses of 100 mg/kg, 200 mg/kg, 400 mg/kg, and extracts of hypericum with a dose of 250 mg/kg, 500 mg/kg and DMSO (control) with the same volume of 15 minutes prior to the assessment of sedative and sleep (sleep duration induced with ketamine dose and 40 mg/kg were injected intraperitoneally).

Results: The results indicate a significant increase in sleep time induced by ketamine in the treatment groups with high and low doses of valerian extracts and the hypericum is significant at the 0.01 level.

Conclusions: The results show that the extract of valerian in the dose of 200 mg/kg in compress of dose of hypericum 500 mg/kg contains the significant anesthetic effects.


Nardostachys Hypericum Ketamine Rat Sedative

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