Effects of drug therapy of visceral leishmaniasis on serum level of IFN-γ, IL-10 and IL-12 in visceral leishmaniasis patients

AUTHORS

abolfazl khoshdel 1 , * , abdolvahab alborzi 2 , manoochehr Rasouli 2 , elham Taheri 3

1 Dept of Pediatrics, Shahrekord University of Medical Sciences and Health Services, Shahrekord. Iran

2 Professor Alborzi Clinical Microbiology Research Center, Namazi Hospital, Shiraz University of Medical Sciences and Health Services, Shiraz, Iran

3 General Physician, Shaharekord University of Medical Sciences and Health Services, Shahrekord, Iran.

How to Cite: khoshdel A, alborzi A, Rasouli M, Taheri E. Effects of drug therapy of visceral leishmaniasis on serum level of IFN-γ, IL-10 and IL-12 in visceral leishmaniasis patients, Zahedan J Res Med Sci. 2008 ; 10(1):e92278.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 10 (1); e92278
Published Online: March 03, 2008
Article Type: Research Article
Received: February 11, 2008
Accepted: June 24, 2008

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Leishmaniosis has remained a serious public health problem in several parts of the developing world. Effective prophylacyic measurements are hampered by imprecise understanding of different aspects of the disease, including its immunoregulation. A better understanding of immunoregulation in human visceral leishmaniosis may be useful both for designing and evaluating immunoprophylaxis. Materials and Methods: This before-after interventional study investigated immunoregulatory mechanisms among 32 patients with visceral leishmaniasis in Shiraz (Iran) in 2007. The plasma cytokine (IFN-gamma, IL-10 and IL-12) levels of participants were measured before, during active disease and at different periods up to 2 months after treatment. Results: Elevated plasma levels of IFN-γ, IL-10 and IL-12 which were observed during active disease, decreased significantly after treatment. The main candidate for blunting IFN- γ activity seems to be IL-10, since the level of this cytokine which highly elevated in plasma decreased sharply after treatment (Before treatment 88.3±77.5, after treatment 25±18.3, 2months after treatment 517±1.9). difference between samples was significant (P<0/05) Discussion: Results suggest that IFN- γ and IL-10 are the molecules most likely involved in determining fate of the disease. After treatment, there is a long delay before the immune profile returns to its normal level which precludes using plasma cytokine levels as criteria for certain cure diagnosis of the disease.

Keywords

visceral leishmaniosis Cytokine IFN-γ IL-10

© 2008, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

The body is available in pdf file.

References

  • 1.

    The references are available in pdf file.

  • COMMENTS

    LEAVE A COMMENT HERE: