Effects of Echinacea Purpurea onWound Healing after Arsenic Induced Skin Necrosis

AUTHORS

Annahita Rezaie 1 , * , Hossein Najafzadeh 2 , Mahdi Poormahdi-Broojeni 3 , Babak Mohammadian 1 , Marzieh Heidari 4

1 Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

2 Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

3 Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

4 Graduated in Veterinary Medicine, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran

How to Cite: Rezaie A , Najafzadeh H , Poormahdi-Broojeni M, Mohammadian B, Heidari M. Effects of Echinacea Purpurea onWound Healing after Arsenic Induced Skin Necrosis, Zahedan J Res Med Sci. 2013 ; 15(11):e92787.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (11); e92787
Published Online: January 26, 2013
Article Type: Research Article
Received: January 19, 2012
Revised: May 15, 2012
Accepted: July 03, 2012

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Abstract

Background: Evaluation of healing effects of Echinacea extract in Arsenic induced dermal necrosis in rat is the objective of this study.
Materials and Methods: In this experimental study 20 male Wistar rats were divided to 2 groups. Dermal necrosis was induced by subcutaneously arsenic injection (4mg/kg) for 10 days. In group 2, after arsenic receiving, Echinacea were injected intraperitoneally (400mg/kg). After last day of injection, rats were euthanizes and pathologic samples were collected from dermal ulcers.
Results: Histopathologic results revealed necrosis of different dermal layers in arsenic group. There were inflammatory exudates instead of impaired structures. In group 2, there were granulation tissue with high cellularity and new vessels.
Conclusion: According to this research findings arsenic can induce dermal necrosis which is a good animal model for dermatologic researches and also Echinacea has healing effects and can protect and limit the Arsenic effects.

Keywords

Arsenic Necrosis Echinacea purpura Wound healing

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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