Antiviral Effect Assay of Aqueous Extract of Echium Amoenum-L against HSV-1

AUTHORS

Maliheh Farahani 1 , *

1 Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran

How to Cite: Farahani M. Antiviral Effect Assay of Aqueous Extract of Echium Amoenum-L against HSV-1, Zahedan J Res Med Sci. 2013 ; 15(8):e92910.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (8); e92910
Published Online: August 05, 2012
Article Type: Research Article
Received: April 05, 2012
Revised: June 22, 2012
Accepted: August 05, 2012

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Abstract

Background: Medicinal plants have been used for different diseases in past. There is an
increasing need for substances with antiviral activity since the treatment of viral infections
with the available antiviral drugs often leads to the problem of viral resistance. Therefore
in the present study Echium amoenum L plant with ethnomedical background was
screened for antiviral activity against HSV-1 in different times.
Materials and Methods: Flower part of Echium amoenum L plant collected from Iran was
extracted with different methods to obtain crude aqueous extract. This extract was
screened for its cytotoxicity against Hep II cell line by CPE assay. Antiviral properties of
the plant extract were determined by cytopathic effect inhibition assay.
Results: Echium amoenum L extract exhibited significant antiviral activity at non toxic
concentrations to the cell line used. Findings indicated that plant extract has the most
antiviral activity when it used an hour after virus inoculation.
Conclusion: Echium amoenum L plant had not toxic effect at highest concentrations to the
cell lines used and showed the most antiviral activity when it used an hour after virus
inoculation. Further research is needed to elucidate the active constituents of this plant
which may be useful in the development of new and effective antiviral agents.

Keywords

Antiviral effect Echium amoenum L HSV-1

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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