The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats

AUTHORS

Zia Fallah Mohammadi 1 , * , Mojtaba Ebrahimzadeh 1 , akbar hajizadeh moghaddam 2

1 Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran

2 Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran

How to Cite: Fallah Mohammadi Z , Ebrahimzadeh M, hajizadeh moghaddam A. The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats, Zahedan J Res Med Sci. 2013 ; 15(5):e92984.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 15 (5); e92984
Published Online: January 07, 2012
Article Type: Research Article
Received: May 05, 2019
Accepted: December 06, 2011

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Abstract

Background : Amyloid Beta (1-42) is derived from amyloid precursor protein and plays a critical role in AD pathogenesis. The purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain Amyloid beta (1-42) in the diabetic rats induced with alloxan.
Materials and Methods : 28 male rats weight 185±1 were assigned randomly to 4 groups (N=7): normal control (C), training (T), control-diabetic (CD) and diabetic-training (DT). Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) intraperitoneal.
Results : 6 weeks of voluntary wheel running decreased the cortex Aβ1-42 in T and DT groups. Aβ1-42 levels significantly decreased in the T and DT in compare with C and CD (p<0.001), respectively. Also Aβ1-42 levels significantly increased in the CD in compare with C (p<0.001).
Conclusion : voluntary exercise had positive effects on decreasing of Aβ1-42 levels during 6 weeks. Therefore it can be recommended as therapeutic strategy for diabetes.

Keywords

Aβ1-42 Voluntary wheel running Rats

© 2013, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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