Effects of Oral Acyclovir on the Treatment of Pityriasis rosea (PR)

AUTHORS

afshin taheriazam 1 , *

1 Dept of Dermatology, Faculty of Medicine Zahedan University of Medical Sciences and Health Services, Zahedan. Iran

How to Cite: taheriazam A. Effects of Oral Acyclovir on the Treatment of Pityriasis rosea (PR), Zahedan J Res Med Sci. 2008 ; 10(1):e94749.

ARTICLE INFORMATION

Zahedan Journal of Research in Medical Sciences: 10 (1); e94749
Published Online: December 04, 2007
Article Type: Research Article
Received: January 02, 2006
Accepted: August 24, 2007

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Abstract

Background: Pityriasis rosea (PR) is an acute self limiting skin disease whose etiology, in spite of, several studies is still unknown. However, there is a hypothesis suggesting that infectious agents specially viral agents like HHV6 and HHV7are responsible for PR.
Materials and Methods: A double-blind, placebo-controlled trial study was performed at a dermatology clinic in Zahedan (Iran) in 2006. One hundred and twenty nine consecutive patients with PR were randomly assigned into two groups: treatment group (n = 65) who were treated for 1 week with oral acyclovir (800 mg 5 times daily) and control group (n = 64) who received placebo (Vitamin E; 100 mg 2 times daily). All the patients were assessed at admission (week 0) and at weeks 1 and 2.
Results: The ratio of female to male participants was 2 to 1consisting 88 females (68/2%) and 41 males(31/8%).In the 7th and 14th days of assessment (P=0/001) response to complete treatment and relative treatment in case group showed a statistically significant increase compared to control group. Formation of new lesions in the 1st week (P=0/006) and in the 2nd week (P=0.001) had a statistically significant increase in control group in comparison with the case group.
Discussion:  We could not evaluate the efficacy of treatment in virus replication since the rate of HHV7 and HHV6 infection is high; moreover, evaluation of the antibody titer in such patients’ serum especially in adults does not provide valuable information. However, the results of this study showed that high dose of acyclovir can be effective in treatment of patients with PR with sever skin eruption specially if it is administered in the first week of skin eruptions when the replication of virus has a high rate.

Keywords

Pityriasis rosea acyclovir HHV6 HHV7

© 2008, Zahedan Journal of Research in Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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