Zahedan Journal of Research in Medical Sciences

Published by: Kowsar

Comparison of the Effects of Acetaminophen Plus Ibuprofen to Treat Fever Than any of the Two Alone in Febrile Children

Noor Mohammad Noori 1 , Ghasem Miri-Aliabad 1 , Tahereh Boryri 2 , Alireza Teimouri 1 , * and Gholamreza Soleimani 1
Authors Information
1 Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran
2 Department of Midwifery, Faculty of Nursing and Midwifery, Zahedan University of Medical Sciences, Zahedan, IR Iran
Article information
  • Zahedan Journal of Research in Medical Sciences: August 2016, 18 (8); e7952
  • Published Online: July 31, 2016
  • Article Type: Research Article
  • Received: April 23, 2014
  • Accepted: October 12, 2014
  • DOI: 10.17795/zjrms-7952

To Cite: Noori N M, Miri-Aliabad G, Boryri T, Teimouri A, Soleimani G. Comparison of the Effects of Acetaminophen Plus Ibuprofen to Treat Fever Than any of the Two Alone in Febrile Children, Zahedan J Res Med Sci. 2016 ; 18(8):e7952. doi: 10.17795/zjrms-7952.

Abstract
Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Hay AD, Costelloe C, Redmond NM, Montgomery AA, Fletcher M, Hollinghurst S, et al. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. BMJ. 2008; 337: 1302[DOI][PubMed]
  • 2. Sarrell EM, Wielunsky E, Cohen HA. Antipyretic treatment in young children with fever: acetaminophen, ibuprofen, or both alternating in a randomized, double-blind study. Arch Pediatr Adolesc Med. 2006; 160(2): 197-202[DOI][PubMed]
  • 3. Baraff LJ, Bass JW, Fleisher GR, Klein JO, McCracken GH, Powell KR, et al. Practice guideline for the management of infants and children 0 to 36 months of age with fever without source. Agency for Health Care Policy and Research. Ann Emerg Med. 1993; 22(7): 1198-210[PubMed]
  • 4. Hollinghurst S, Redmond N, Costelloe C. Paracetamol, plus ibuprofen for the treatment of fever in children: economic evaluation of a randomized controlled trial. BMJ. 2008; 337: 1490
  • 5. Vauzelle-Kervroëdan F, d’Athis P, Pariente-Khayat A, Debregeas S, Olive G, Pons G, et al. Equivalent antipyretic activity of ibuprofen and paracetamol in febrile children. J Pediatr. 1997; 131(5): 683-7
  • 6. Brown RD, Kearns GL, Wilson JT. Integrated pharmacokinetic-pharmacodynamic model for acetaminophen, ibuprofen, and placebo antipyresis in children. J Pharmacokinet Biopharm. 1998; 26(5): 559-79[PubMed]
  • 7. Nouri NM, Rajaei S, Boriri T. Antipyretic efficacy of acetaminophen and ibuprofen in children aged 6 months to 10 years. Med J Hormozgan Univ. 2008; 12: 1-6
  • 8. Sullivan JE, Farrar HC. Fever and antipyretic use in children. Pediatrics. 2011; 127(3): 580-7[DOI][PubMed]
  • 9. Hay AD, Redmond NM, Costelloe C, Montgomery AA, Fletcher M, Hollinghurst S, et al. Paracetamol and ibuprofen for the treatment of fever in children: the PITCH randomised controlled trial. Health Technol Assess. 2009; 13(27): 1-163[DOI][PubMed]
  • 10. Purssell E. Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone. Arch Dis Child. 2011; 96(12): 1175-9[DOI][PubMed]
  • 11. Hollinghurst S, Redmond N, Costelloe C, Montgomery A, Fletcher M, Peters TJ, et al. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): economic evaluation of a randomized controlled trial. BMJ. 2008; 337(1490:): 1-8[DOI]
  • 12. Keen J. Antipyretic drugs for children. BMJ. 2006; 333(7557): 4-5
  • 13. Southey ER, Soares-Weiser K, Kleijnen J. Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. Curr Med Res Opin. 2009; 25(9): 2207-22[DOI][PubMed]
  • 14. Paul IM, Sturgis SA, Yang C, Engle L, Watts H, Berlin CM. Efficacy of standard doses of Ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children. Clin Ther. 2010; 32(14): 2433-40[DOI][PubMed]
  • 15. Hoover L. AAP reports on the use of antipyretics for fever in children. Am Fam Physician. 2012; 85(5): 518-9[PubMed]
  • 16. Perrott DA, Piira T, Goodenough B, Champion GD. Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis. Arch Pediatr Adolesc Med. 2004; 158(6): 521-6[DOI][PubMed]
  • 17. Meremikwu MM, Oyo‐Ita A. Paracetamol versus placebo or physical methods for treating fever in children. Cochrane Library. 2002; [DOI]
  • 18. Kokki H, Kokki M. Ketoprofen versus paracetamol (acetaminophen) or ibuprofen in the management of fever: results of two randomized, double-blind, double-dummy, parallel-group, repeated-dose, multicentre, phase III studies in children. Clin Drug Investig. 2010; 30(6): 375-86[DOI][PubMed]
  • 19. Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, et al. Combined and alternating paracetamol and ibuprofen therapy for febrile children. Evid Based Child Health A Cochrane Rev J. 2014; 9(3): 675-729
  • 20. Smith C, Goldman RD. Alternating acetaminophen and ibuprofen for pain in children. Can Fam Physician. 2012; 58(6): 645-7[PubMed]
  • 21. Niehues T. The febrile child: diagnosis and treatment. Dtsch Arztebl Int. 2013; 110(45): 764-73[DOI][PubMed]
  • 22. Wong T, Johnson DW, Ganshorn H, Maconochie IK, Hartling L, Stang AS. Combined and alternating paracetamol and ibuprofen therapy for fever in children. Cochrane Library. 2012;
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments